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K9 Advantix II for Dogs

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California Residents: Prop. 65 Warning

This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. For more information, go to www.P65Warnings.ca.gov

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Product Description
K9 Advantix II is a topical prevention and treatment of ticks, fleas, eggs and mosquitoes for monthly use on dogs and puppies 7 weeks of age and older. See the AKCRx Flea and Tick Chart to find which flea and tick product is best for your pet.
What is K9 Advantix II for Dogs?
K9 Advantix II is a topical prevention of external parasites on dogs. Controls fleas and ticks, flea eggs and mosquitoes. Repels and kills ticks including Deer ticks (vector of Lyme disease), American dog ticks (vector of Rocky Mountain spotted fever), Brown dog ticks (vector of ehrlichiosis), and Lone Star ticks for up to four weeks Kills 98-100% of the fleas on dogs within 12 hours and continues to prevent infestations for at least four weeks . K9 Advantix II kills fleas before they lay eggs. Following contact with a K9 Advantix II, Larval flea stages in the dog's surroundings are killed in the treated dog . It also repels and kills mosquitoes for up to four weeks •
Who is K9 Advantix II for Dogs for?
Dogs and Puppies 7 weeks or older
Why use K9 Advantix II for Dogs?
- Convenient, easy to apply. K9 Advantix II remains effective after bathing and swimming. - Reduces the risk of parasite-transmitted diseases and the stress for the pet - Ends flea life cycle by preventing flea offspring (eggs, pupae, and larvae) from maturing into adult fleas - Provides one month of protection against ticks, flea bites, mosquitoes and biting flies. - Repels biting flies and kills chewing lice - Over the counter topical, Kills fleas, ticks, lice and mosquitoes
How does K9 Advantix II for Dogs work?
When Advantage is applied to your pet, it spreads on the surface of the skin at the hair root level, aided by body movement, to provide whole body coverage. The revolutionary chemistry causes the flea's nervous system to become impaired, and the flea dies. Reinfesting fleas, which likely come from the pet's environment or outdoors, will be killed within two hours, with protection against further flea infestation for up to a month.
Active Ingredients(s):
Imidacloprid 8.80% Permethrin* 44.00% Pyriproxyfen 0.44% Other Ingredients 46.76%
How is K9 Advantix II for Dogs sold?
Sold in 2, 4, 6, and 12 month supplies based on your dog's weight. Boxes are color coded to your dog's weight.
  • Green: Up to 10 pounds
  • Teal: 11 - 20 pounds
  • Red: 21 - 55 pounds
  • Blue: Over 55 pounds
What are the side effects of K9 Advantix II for Dogs?
In rare cases, some dogs have experienced weakness, depression, and unsteadiness between 6 and 9 days after application with Advantage Multi for Dogs. The signs resolved without intervention by day 10 post-application. The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours.
What special precautions are there?
In households with cats, separate the treated dog for 12 hours until the product is thoroughly dry. Visit K9 Advantix II Adverse Reactions if your pet has been experiencing adverse reactions to K9 Advantix II.
What to do if overdose?
Contact your nearest animal emergency clinic.
How can I store K9 Advantix II for Dogs?
Should be stored in a cool dry place. Do not refrigerate.
Helpful Tips:
Treated dogs should not be handled especially by children until the application site is dry. This may be ensured by treating the dogs e.g. in the evening. In this case, recently treated dogs should not be allowed to sleep together with their owner, especially children.
Advantix® is easy to apply – one dose, once or twice a month, simply applied onto the skin of the animals and available in four different pipette sizes. A small dog below 4 kg weight requires no more than a single spot on its neck with the advantix® 0.4 ml pipette. For a big dog of more than 25 kg weight the advantix® 4.0 ml pipette should be applied on four spots along its back.
With monthly treatment the pet gains year-round protection against nasty parasites. For dermal use only.
The dog should be standing for easy application. The entire contents of the advantix® pipette should be applied evenly to four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the pipette on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog.
Indications for use
Advantix® Spot on is designed for dermal application. Dogs with body weights under 10 kg should be treated at a single spot. The recommended minimum dose is: 10 mg/kg body weight (bw) Imidacloprid and 50 mg/kg body weight (bw) Permethrin.

Dogs (kg bw)

Trade name

Volume (ml)

Imidacloprid (mg/kg bw)

Permethrin (mg/kg bw)

<= 4 kg

advantix® Spot-on for dogs up to 4 kg

0.4 ml

minimum of 10

minimum of 50

>4 up to 10 kg

advantix®  Spot-on for dogs over 4 up to 10 kg

1.0 ml

10 - 25

50 - 125

>10 up to 25 kg

advantix®  Spot-on for dogs over 10 up to 25 kg

2.5 ml

10 - 25

50 - 125

>25 up to 40 kg

advantix® Spot-on for dogs over 25 kg

4.0 ml

10 - 16

50 - 80

Treatment Recommendations
To reduce re-infestation from emergence of new fleas, it is recommended to treat all dogs in a household. Other per animals living in the same household should also be treated with a suitable product. To aid further in reducing environmental challenge, the additional use of a suitable environmental treatment against adult fleas and their developmental stages is recommended. 
Main Ingredients
Active Ingredients  /   % By Weight
Imidacloprid                      8.80%
Permethrin*                      44.00%
Pyriproxyfen                      0.44%
Other Ingredients              46.76%
Total                                 100.0%
*cis/trans ratio: max 55% (±) cis and min 45% (±) tr