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Click on image to open expanded view Item No. 51631

Simparica Trio Chewable Tablets for Dogs Rx

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Product Description
Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis (black-legged tick) for 5 weeks (35 days), and with Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick) for 4 weeks (28 days). For the treatment and prevention of flea infestations for 5 weeks (35 days); Simparica Trio kills adult fleas. For the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections.
Who is Simparica Trio Chewable Tablets for Dogs for?
Dogs and Puppies (8 weeks of age and older and weighing 2.8 lbs or more)
Why use Simparica Trio Chewable Tablets for Dogs?
Prevents heartworms. Treats aand controls ticks (lone star ticks, black legged ticks, gulf coast ticks, american dog ticks, brown dog ticks). Treats and prevents flea infestations. Treats and controls roundworms, and adult hookworm infections.
How does Simparica Trio Chewable Tablets for Dogs work?
Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in arthropods. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
Active Ingredients(s):
Sarolaner, Moxidectin, Pyrantel
How is Simparica Trio Chewable Tablets for Dogs sold?
Sold as 1 Month, 3 Month, 6 Month or 12 Month Supply for the following dog weights :
  • 2.8-5.5 lbs
  • 5.5-11 lbs
  • 11-22 lbs
  • 22-44 lbs
  • 44-88 lbs
  • 88-132 lbs
What are the side effects of Simparica Trio Chewable Tablets for Dogs?
Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurological adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurological disorders. Some possible side effects of taking Simparica Trio may include : vomiting, diarrhea, lethargy, anorexia, polyria, hyperactivity or polydypsia.
What special precautions are there?
Keep away from children and animals. The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. Prior to administration of SIMPARICA TRIO dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. SIMPARICA TRIO is not effective against adult D. immitis.
What to do if overdose?
Contact your nearest emergency animal hospital.
How can I store Simparica Trio Chewable Tablets for Dogs?
Store at or below 30*C (86*F)
Dosage and Administration :
The recommended minimum dosage is 1.2 mg/kg (0.54 g/lb) sarolaner, 24 µg/kg (0.011 mg/lb) moxidectin, and 5 mg/kg (2.27 mg/lb) pyrantel (as pyrantel pamoate). 

SIMPARICA TRIO is given orally on a monthly basis. SIMPARICA TRIO needs to be administered every 4 weeks in case of exposure to Amblyomma maculatum, Dermacentor variabilis, and Rhipicephalus sanguineus. In case of tick infestation, accurate tick identification is recommended prior to administering the product.

Body Weight  /  Sarolaner per Tablet (mg)  /  Moxidectin per Tablet (mg)  /  Pyrantel per Tablet (mg)  /  Number of Tablets Administered
2.8 to 5.5 lbs  /              3.0                          /                    0.06                     /                   12.5                  /                               1 
5.5 to 11 lbs   /              6.0                          /                    0.12                     /                    25                    /                               1
11-22 lbs       /               12                          /                    0.24                      /                   50                    /                                1
22-44 lbs      /                24                          /                    0.48                     /                   100                  /                                 1
44-88 lbs      /                48                         /                     0.96                     /                   200                  /                                 1
88-132 lbs    /                72                         /                     1.44                     /                   300                  /                                 1

SIMPARICA TRIO can be offered to the dog with or without food.

Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a monthly dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.
Main Ingredients
Active Ingredients : Sarolaner, Moxidectin, Pyrantel