Trifexis® (spinosad+milbemycin oxime) provides 3-in-1 parasite protection against heartworm, fleas and intestinal parasites. Trifexis® (spinosad + milbemycin oxime) is a monthly, beef-flavored tablet that kills fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm infections. This powerful protection is approved for use in dogs and puppies 8 weeks and older and 5 pounds or more.
What is Trifexis Chewable Tablets for Dogs?
Trifexis is a monthly chewable tablet that protects dogs against fleas and worms. It treats your dog’s intestinal infections from adult hookworms, roundworms, whipworms, and kills adult fleas.
Who is Trifexis Chewable Tablets for Dogs for?
Trifexis is for dogs and puppies 8+ weeks old. Trifexis should not be used on puppies or dogs under 5 lbs.
Why use Trifexis Chewable Tablets for Dogs?
Trifexis for dogs provides 3-in-1 parasite protection.
Get three types of parasite protection in just one monthly tablet.
Kills fleas and prevents infestations.
Prevents heartworm disease.
Treats and controls adult hookworm, roundworm, and whipworm infections.
#1 Prescribed combo parasite protection.
A monthly, beef-flavored tablet that kills adult fleas and prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm and whipworm infections
Trifexis is proven safe in dogs and puppies 8 weeks and older and 5 pounds and greater.
How does Trifexis Chewable Tablets for Dogs work?
Trifexis prevents flea infestations and protects your dog from parasites with one monthly tablet. The main ingredient in Trifexis is spinosad, which prevents and controls flea infestations by killing adult fleas. The primary target of action of spinosad is an activation of nicotinic acetylcholine receptors (nAChRs) in insects. Spinosad, starts to work within 30 minutes to kill fleas and has been proven to kill 100% of all biting fleas within 4 hours. Milbemycin oxime is the other active ingredient in Trifexis and is used to prevent heartworms. Milbemycin oxime kills adult hookworms, roundworms and whipworms. It kills the immature form of the heartworm (Dirofilaria immitis), which is transmitted to dogs by mosquitoes.
Elanco Animal Health
Spinosad and Milbemycin Oxime
How is Trifexis Chewable Tablets for Dogs sold?
Trifexis is sold in 3, 6, and 12 month packs for dogs ranging from 5 to 120 lbs. Select the appropriate Trifexis product for your dog’s weight:
Product Label Color / Dog’s Weight
- Pink 5 - 10 lbs
Orange 10.1 - 20 lbs
Green 20.1 - 40 lbs
Blue 40.1 - 60 lbs
Brown 60.1 - 120 lbs
What are the side effects of Trifexis Chewable Tablets for Dogs?
The most common adverse reactions recorded in clinical trials were vomiting, pruritus, lethargy and diarrhea. If vomiting occurs within an hour of administration, you can give your dog another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting.
What special precautions are there?
Your dog should be tested for heartworm infection before starting Trifexis.
Trifexis has not been evaluated for safe use in breeding males. Use with caution in dogs with pre-existing epilepsy.
Contact your nearest emergency animal hospital in the event of overdose or adverse reaction while using Trifexis.
How can I store Trifexis Chewable Tablets for Dogs?
Store Trifexis at room temperature (68-77° F)
Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, your dogs should be tested for existing heartworm infection. Use with caution in breeding females.
Trifexis is an oral medication and does not require you to isolate your dog from other pets during treatment.
Trifexis is a prescribed pet medication for the prevention of fleas and parasites such as roundworm, hookworm and heartworm. Follow your veterinarian's directions on when to give this medication. If you are advised to give it seasonally for heartworm prevention, remember to give it during the mosquito season and 3 months beyond, preferably on the same date each month.
Trifexis should be used as recommended by your veterinarian. If you have difficulty giving the medication to your dog, contact your veterinarian.
Dosages of Trifexis by Weight for Dogs Over 8 Weeks of Age
Weight / Dosage
5-10 lbs 1 Tab (Pink Label box)
10.1 - 20 lbs 1 Tab (Orange Label box)
20.1 - 40 lbs 1 Tab (Green Label box)
40.1 - 60 lbs 1 Tab (Blue Label box)
60.1 - 120 lbs 1 Tab (Brown Label box)
Over 120 lbs Vet’s Prescribed Dosage
If you do not administer Trifexis monthly throughout the year, the final dose must be given no fewer than three months following the last exposure to mosquitoes. Please speak with your vet for any question regarding Trifexis dosage or missed dosages.
Trifexis is manufactured by Elanco Animal Health and contains the following active ingredients:
Active Ingredients / Amount per Tablet
Spinosad 140 mg
Milbemycin Oxime 2.3 mg